UNVEILING THE MYSTERIES OF EPIGENETIC REGULATION
LAB NEWS

Science Fashionistas
Here in Fondufe-Mittendorf lab, we study epigenetics and look great doing it! With outfits like this, it's impossible not to have fun in our lab, and we see no reason not to celebrate it!
https://blogs.plos.org/everyone/2019/07/11/everyone-yvonne-fondufe-mittendorf/

NIEHS Keystone Science Lecture Series
In an NIEHS Keystone Science Lecture Series, Yvonne Fondufe-Mittendorf gave a talk about her research and the potential it has to help us understand possible causes of cancer development.

People Behind Our Research

Congratulations to Rebekah Eleazer!
Congratulations to Rebekah Eleazer for being awarded an NSF fellowship! This award is highly competitive, and we are proud to have Rebekah in our lab!
OUR LAB
Welcome to the Fondufe-Mittendorf lab. Our lab focuses on mechanisms by which chromatin and the epigenome are modulated during normal growth and in response to environmental cues. Our lab uses multifaceted approaches at the interface between biology, toxicology, bioinformatics and medicine, to study how when the modulation of chromatin and epigenomics goes awry, changes in gene expression ensues that then drive disease pathology. Our findings will not only provide a basic mechanistic insight into principles that govern gene regulation but will also inform on gene expression dysregulation in disease pathology and ultimately drug discovery.
Follow us on Twitter!
@fondufeyvonne
PUBLICATIONS
2019
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Latexin regulation by HMGB2 is required for hematopoietic stem cell maintenance.
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PARP1 is a versatile factor in the regulation of mRNA stability and decay; Sci Rep. 9(1):3722.
2018
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Selective inhibition of CTCF binding by iAs directs TET-mediated reprogramming of 5-hydroxymethylation patterns in iAs-transformed cells; Toxicol Appl Pharmacol. 338:124-133.
2017
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Methodology to Identify Poly-ADP-Ribose Polymerase 1 (PARP1)-mRNA Targets by PAR-CLiP; Methods Mol Biol. 2017;1608:211-228
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A comparison of nucleosome organization in Drosophila cell lines; PLoS One12(6):e0178590
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Genome-wide DNA methylation reprogramming in response to inorganic arsenic links inhibition of CTCF binding, DNMT expression and cellular transformation; Sci Rep. 7:41474
2016
To read more of Yvonne's publications, follow this link to PubMed!
LAB MEMBERS
Yvonne Fondufe-Mittendorf
Principal investigator
Meredith Eckstein
Graduate student
I am investigating how dysregulation of histone variants drive nucleosome dynamics in carcinogenesis
Wesley Saintilnord
Graduate student
I investigate how paternal exposure to cadmium modulates sperm DNA methylation.
Elena Matveeva
Research scientist
PARP1-chromatin associations regulate RNA Pol II elongation to drive alternative splicing.
Alex Schomaker
Graduate student
My project involves understanding the epigenetic regulator Methyl CpG-binding Protein 2.
Manana Melikishvili
Research scientist
My research is on regulation of chromatin structure and dynamics to drive gene expression.
Matthew Rea
Postdoctoral fellow
My research seeks to understand epigenetic changes during carcinogenesis.
Rebekah Eleazer
Graduate student
I am investigating the cicrRNA biogenesis and their function in arsenic-carcinogenesis.
Thanks to the high-schoolers, undergrads who made summer 2019 fun.



CONTACT
Inquiries
For any inquiries, questions or commendations, please call: 859-323-0091 or fill out the following form.
Head Office
741 S. Limestone
Lexington, KY 40536
Employment
We are recruiting students and postdoctoral fellows with backgrounds and interests in all areas of biology including RNA biology, chromatin biology, genetics, computational biology/bioinformatics, and biophysics. Please send an email to