UNVEILING THE MYSTERIES OF EPIGENETIC REGULATION

 

LAB NEWS

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Science Fashionistas

Here in Fondufe-Mittendorf lab, we study epigenetics and look great doing it! With outfits like this, it's impossible not to have fun in our lab, and we see no reason not to celebrate it!

https://blogs.plos.org/everyone/2019/07/11/everyone-yvonne-fondufe-mittendorf/

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NIEHS Keystone Science Lecture Series

In an NIEHS Keystone Science Lecture Series, Yvonne Fondufe-Mittendorf gave a talk about her research and the potential it has to help us understand possible causes of cancer development.

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People Behind Our Research

Meet Dr. Yvonne Fondufe-Mittendorf in a featured article of UK NOW!

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Read more>>
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Congratulations to Rebekah Eleazer!

Congratulations to Rebekah Eleazer for being awarded an NSF fellowship! This award is highly competitive, and we are proud to have Rebekah in our lab!

OUR LAB

Welcome to the Fondufe-Mittendorf lab. Our lab focuses on mechanisms by which chromatin and the epigenome are modulated during normal growth and in response to environmental cues. Our lab uses multifaceted approaches at the interface between biology, toxicology, bioinformatics and medicine, to study how when the modulation of chromatin and epigenomics goes awry, changes in gene expression ensues that then drive disease pathology. Our findings will not only provide a basic mechanistic insight into principles that govern gene regulation but will also inform on gene expression dysregulation in disease pathology and ultimately drug discovery.

 

Follow us on Twitter!

@fondufeyvonne
 

PUBLICATIONS

2019

  1. Latexin regulation by HMGB2 is required for hematopoietic stem cell maintenance.

  2. Transcriptional Regulation Factors of the Human Mitochondrial Aspartate/Glutamate Carrier Gene, Isoform 2 (SLC25A13): USF1 as Basal Factor and FOXA2 as Activator in Liver Cells.

  3. PARP1 is a versatile factor in the regulation of mRNA stability and decay; Sci Rep. 9(1):3722.

  4. Coupling of PARP1-mediated chromatin structural changes to transcriptional RNA polymerase II elongation and cotranscriptional splicing; Epigenetics Chromatin12(1):15.

 

2018

  1. Selective inhibition of CTCF binding by iAs directs TET-mediated reprogramming of 5-hydroxymethylation patterns in iAs-transformed cells; Toxicol Appl Pharmacol. 338:124-133.

 

2017

  1.  Transcriptome-wide identification of the RNA-binding landscape of the chromatin-associated protein PARP1 reveals functions in RNA biogenesis; Cell Discov. 3:17043.

  2. Erratum to: Methodology to Identify Poly-ADP-Ribose Polymerase 1 (PARP1)-mRNA Targets by PAR-CLiP; Methods Mol Biol. 2017;1608

  3. Methodology to Identify Poly-ADP-Ribose Polymerase 1 (PARP1)-mRNA Targets by PAR-CLiP; Methods Mol Biol. 2017;1608:211-228

  4. Microarray dataset of transient and permanent DNA methylation changes in HeLa cells undergoing inorganic arsenic-mediated epithelial-to-mesenchymal transition; Data Brief13:6-9

  5. A comparison of nucleosome organization in Drosophila cell lines; PLoS One12(6):e0178590

  6. Transient and permanent changes in DNA methylation patterns in inorganic arsenic-mediated epithelial-to-mesenchymal transition; Toxicol Appl Pharmacol. 331:6-17

  7. Genome-wide DNA methylation reprogramming in response to inorganic arsenic links inhibition of CTCF binding, DNMT expression and cellular transformation; Sci Rep. 7:41474

  8. Epigenomic reprogramming in inorganic arsenic-mediated gene expression patterns during carcinogenesis; Rev Environ Health. 32(1-2):93-103

 

2016

  1.  Comparative analysis of linker histone H1, MeCP2, and HMGD1 on nucleosome stability and target site accessibility. Sci Rep. 6:33186

  2. Involvement of PARP1 in the regulation of alternative splicing. Cell Discov. 2:15046

  3. Quantitative Mass Spectrometry Reveals Changes in Histone H2B Variants as Cells Undergo Inorganic Arsenic-Mediated Cellular Transformation. Mol Cell Proteomics15(7):2411-22

 

To read more of Yvonne's publications, follow this link to PubMed!

LAB MEMBERS

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Yvonne Fondufe-Mittendorf

Principal investigator

 

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Meredith Eckstein

Graduate student

I am investigating how dysregulation of histone variants drive nucleosome dynamics in carcinogenesis 

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Wesley Saintilnord

Graduate student

I investigate how paternal exposure to cadmium modulates sperm DNA methylation.

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Elena Matveeva

Research scientist

PARP1-chromatin associations regulate RNA Pol II elongation to drive alternative splicing. 

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Alex Schomaker

Graduate student

My project involves understanding the epigenetic regulator Methyl CpG-binding Protein 2.

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Manana Melikishvili

Research scientist

My research is on regulation of chromatin structure and dynamics to drive gene expression.

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Matthew Rea

Postdoctoral fellow

My research seeks to understand epigenetic changes during carcinogenesis.

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Rebekah Eleazer

Graduate student

I am investigating the cicrRNA biogenesis and their function in arsenic-carcinogenesis.

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Thanks to the high-schoolers, undergrads who made summer 2019 fun.

 

CONTACT

Inquiries

For any inquiries, questions or commendations, please call: 859-323-0091 or fill out the following form.

Thanks for submitting!

Head Office

741 S. Limestone

Lexington, KY 40536

y.fondufe-mittendorf@uky.edu

Employment

We are recruiting students and postdoctoral fellows with backgrounds and interests in all areas of biology including RNA biology, chromatin biology, genetics, computational biology/bioinformatics, and biophysics. Please send an email to

y.fondufe-mittendorf@uky.edu