FONDUFE-MITTENDORF LABORATORY

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@fondufeyvonne

PUBLICATIONS

2019

1. Latexin regulation by HMGB2 is required for hematopoietic stem cell maintenance.

2. Transcriptional Regulation Factors of the Human Mitochondrial Aspartate/Glutamate Carrier Gene, Isoform 2 (SLC25A13): USF1 as Basal Factor and FOXA2 as Activator in Liver Cells.

3. PARP1 is a versatile factor in the regulation of mRNA stability and decay; Sci Rep. 9(1):3722.

4. Coupling of PARP1-mediated chromatin structural changes to transcriptional RNA polymerase II elongation and cotranscriptional splicing; Epigenetics Chromatin12(1):15.

2018

1. Selective inhibition of CTCF binding by iAs directs TET-mediated reprogramming of 5-hydroxymethylation patterns in iAs-transformed cells; Toxicol Appl Pharmacol. 338:124-133.

2017

1.  Transcriptome-wide identification of the RNA-binding landscape of the chromatin-associated protein PARP1 reveals functions in RNA biogenesis; Cell Discov. 3:17043.

2. Erratum to: Methodology to Identify Poly-ADP-Ribose Polymerase 1 (PARP1)-mRNA Targets by PAR-CLiP; Methods Mol Biol. 2017;1608

3. Methodology to Identify Poly-ADP-Ribose Polymerase 1 (PARP1)-mRNA Targets by PAR-CLiP; Methods Mol Biol. 2017;1608:211-228

4. Microarray dataset of transient and permanent DNA methylation changes in HeLa cells undergoing inorganic arsenic-mediated epithelial-to-mesenchymal transition; Data Brief13:6-9

5. A comparison of nucleosome organization in Drosophila cell lines; PLoS One12(6):e0178590

6. Transient and permanent changes in DNA methylation patterns in inorganic arsenic-mediated epithelial-to-mesenchymal transition; Toxicol Appl Pharmacol. 331:6-17

7. Genome-wide DNA methylation reprogramming in response to inorganic arsenic links inhibition of CTCF binding, DNMT expression and cellular transformation; Sci Rep. 7:41474

8. Epigenomic reprogramming in inorganic arsenic-mediated gene expression patterns during carcinogenesis; Rev Environ Health. 32(1-2):93-103

2016

1.  Comparative analysis of linker histone H1, MeCP2, and HMGD1 on nucleosome stability and target site accessibility. Sci Rep. 6:33186

2. Involvement of PARP1 in the regulation of alternative splicing. Cell Discov. 2:15046

3. Quantitative Mass Spectrometry Reveals Changes in Histone H2B Variants as Cells Undergo Inorganic Arsenic-Mediated Cellular Transformation. Mol Cell Proteomics15(7):2411-22

To read more of Yvonne's publications, follow this link to PubMed!

LAB MEMBERS

Yvonne Fondufe-Mittendorf

Principal investigator

Meredith Eckstein

Graduate student

I am investigating how dysregulation of histone variants drive nucleosome dynamics in carcinogenesis 

Wesley Saintilnord

Graduate student

I investigate how paternal exposure to cadmium modulates sperm DNA methylation.

Elena Matveeva

Research scientist

PARP1-chromatin associations regulate RNA Pol II elongation to drive alternative splicing. 

Alex Schomaker

Graduate student

My project involves understanding the epigenetic regulator Methyl CpG-binding Protein 2.

Manana Melikishvili

Research scientist

My research is on regulation of chromatin structure and dynamics to drive gene expression.

Matthew Rea

Postdoctoral fellow

My research seeks to understand epigenetic changes during carcinogenesis.

Rebekah Eleazer

Graduate student

I am investigating the cicrRNA biogenesis and their function in arsenic-carcinogenesis.

Thanks to the high-schoolers, undergrads who made summer 2019 fun.

CONTACT

Inquiries

For any inquiries, questions or commendations, please call: 859-323-0091 or fill out the following form.

Head Office

741 S. Limestone

Lexington, KY 40536

Employment

We are recruiting students and postdoctoral fellows with backgrounds and interests in all areas of biology including RNA biology, chromatin biology, genetics, computational biology/bioinformatics, and biophysics. Please send an email to